The major progress in organic synthesis since 2005 is briefly surveyed in two parts.The first part deals with some of the most impressive advances in the synthetic methodology,which includes:(1) metal-mediated synthetic reactions,with an emphasis on the olefin metathesis and gold-mediated reactions;(2) free radical-based organic synthesis;(3) synthetic transformations performed in a "one-pot" manner involving either tandem reactions or multicomponent reactions;(4) asymmetric reactions catalyzed by metal and organo-catalysts.The major advances in total synthesis of some complex natural products with significant biological activities are presented in the second part,with detailed illustrations of ten selected molecules,including dragmacidin F,abyssomicin C,11-acetoxy-4-deoxyasbestinin D,pentacycloanammoxic acid,UCS 1025A,(-)-merrilactone A,nigellamine A2,( +)-saxitoxin,and Tamiflu (an artificially designed natural product-like molecule).An array of complicated structures of the natural products synthesized over the last two years is also listed to serve as a convenient lead to the original literature for the prospective interested readers.