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莪术 Curcuma zedoaria(Berg.)Rosc.为常用中药,其根茎有行气、破血、消积之功效,用于妇女血瘀经闭。在日本用作芳香健胃药。1971年,日本 Hikino 等[J Chem Soc(c),1971:688]从莪术中分离得到蓬莪术环氧酮(zederone),并确定其结构(包括绝对构型)为Ⅰ式(中药大辞典即采用此式),此式在相当长时间内得到广泛的承认和引用。1987年,蔡阳等[Chem Pharm Bull,1987,35(2):924～927]根据蓬莪术环氧酮及其它来自莪术化合物的生物合成路线,在用高分辨核磁共振仪进行再研究时,发现原文献所称的环氧环上4位的甲基与5位的氢之
Curcuma zedoaria (Berg.) Rosc. is a commonly used traditional Chinese medicine, its rhizomes have the effect of qi, blood, and consumer products, and they are used for women’s blood stasis. Used as a fragrant stomach in Japan. In 1971, Japan’s Hikino et al [J Chem Soc (c), 1971:688] isolated Zederone from Curcuma and identified its structure (including absolute configuration) as Form I (Chinese Dictionary). Using this formula), this formula has been widely recognized and quoted for quite a long time. In 1987, Chua Yang et al. [Chem Pharm Bull, 1987, 35(2): 924-927] conducted a re-study with a high-resolution NMR spectrometer based on the biosynthetic route of camphor oxide and other compounds from Curcuma. It was found in the original literature that the 4-methyl and 5-hydrogen of the epoxy ring