患者,男性,18岁,生后无眉毛,头发稀少。怕热,从不出汗,喜冷水浴,上学时不能参加体育活动和劳动。牙齿缺少,不能咀嚼食物,需吃流质或半流质饮食。无智力障碍。家族史:父母发育正常,非近亲结婚,母亲怀孕期间无罹病史,其母孕5产4存2,早产1人, Patient, male, 18 years old, without eyebrows after birth, with sparse hair. Afraid of heat, never sweating, like cold water bath, can not participate in physical activity and work when going to school. Lack of teeth, can not chew food, need to eat liquid or semi-liquid diet. No mental retardation. Family history: normal parental development, non-relatives married, the mother had no history of pregnancy during pregnancy, the mother’s pregnancy 5 5 4 deposit 2, 1 premature birth,