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目的探讨喉鳞状细胞癌组织中O6-甲基鸟嘌呤DNA甲基转移酶(MGMT)、表皮生长因子受体(EGFR)的表达与临床病理特征及其相互之间的关系,研究其在肿瘤发生发展以及治疗中的作用。方法采用免疫组织化学染色法检测MGMT、EGFR的表达,分析103例喉癌组织标本与临床病理特征的关系。结果 MGMT的表达与分化程度、T分期以及临床分期呈正相关(χ~2为13.302、8.394、11.403,P值分别为0.001、0.039、0.010<0.05);EGFR的表达与T分期以及临床分期呈正相关(χ~2为14.933、16.603,P值分别为0.002、0.001<0.05)。分层分析发现,MGMT、EGFR两者的表达强度存在正相关(χ~2=5.369,P=0.019<0.05)。结论喉鳞状细胞癌中M GM T、EGFR的表达与T分期、临床分期均有相关性,测定两者的表达水平可评估喉鳞状细胞癌的恶性程度并指导喉癌的治疗。
Objective To investigate the expression of O6-methylguanine DNA methyltransferase (MGMT) and epidermal growth factor receptor (EGFR) in laryngeal squamous cell carcinoma and its clinicopathological features and their relationship with each other, The development and treatment of the role. Methods Immunohistochemical staining was used to detect the expression of MGMT and EGFR in 103 specimens of laryngeal carcinoma and their clinicopathological characteristics. Results The expression of MGMT was positively correlated with the degree of differentiation, T stage and clinical stage (χ ~ 2 = 13.302,8.394,11.403, P = 0.001,0.039,0.010 <0.05). The expression of EGFR was positively correlated with T stage and clinical stage (χ ~ 2 was 14.933,16.603, P values were 0.002,0.001 <0.05). By stratified analysis, there was a positive correlation between the expression intensity of MGMT and EGFR (χ ~ 2 = 5.369, P = 0.019 <0.05). Conclusion The expressions of M GM T and EGFR in laryngeal squamous cell carcinoma are correlated with T stage and clinical stage. The expression of M GM T and EGFR in laryngeal squamous cell carcinoma can be evaluated for the malignant degree of laryngeal squamous cell carcinoma and the treatment of laryngeal carcinoma.