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目的探究氯吡格雷联合钙拮抗剂治疗老年冠状动脉粥样硬化性心脏病(冠心病)的临床疗效。方法选取邓州市中心医院2013年6月—2015年6月收治的160例老年冠心病患者,按照时间先后顺序分为对照组和观察组,各80例。对照组患者给予氯吡格雷治疗,观察组患者给予氯吡格雷联合钙拮抗剂治疗。其中,观察组患者再分为硝苯地平组与地尔硫卓艹组,各40例。地尔硫卓艹组接受地尔硫卓艹治疗,硝苯地平组接受硝苯地平治疗。观察两组患者的临床疗效、不良心血管事件发生情况。结果观察组患者总有效率高于对照组,硝苯地平组总有效率高于地尔硫卓艹组,差异有统计学意义(P<0.05)。观察组与对照组患者不良心血管事件发生率比较,差异无统计学意义(P>0.05);硝苯地平组不良心血管事件发生率低于地尔硫卓艹组,差异有统计学意义(P<0.05)。结论氯吡格雷联合钙拮抗剂治疗老年冠心病的疗效较好,安全性高。
Objective To investigate the clinical efficacy of clopidogrel combined with calcium antagonist in the treatment of elderly patients with coronary atherosclerotic heart disease (CHD). Methods A total of 160 elderly patients with coronary heart disease admitted from June 2013 to June 2015 in Dengzhou Central Hospital were divided into control group and observation group according to time sequence, 80 cases each. Patients in the control group were treated with clopidogrel, and patients in the observation group were treated with clopidogrel combined with calcium antagonists. Among them, the observation group was subdivided into nifedipine group and diltiazem group, 40 cases each. Diltiazem group received diltiazem treatment, nifedipine group received nifedipine treatment. To observe the clinical efficacy of two groups of patients, adverse cardiovascular events. Results The total effective rate of observation group was higher than that of control group. The total effective rate of nifedipine group was higher than that of diltiazem group (P <0.05). There was no significant difference in incidence of adverse cardiovascular events between the observation group and the control group (P> 0.05). The incidence of adverse cardiovascular events in the nifedipine group was lower than that in the diltiazem group (P <0.05) ). Conclusion Clopidogrel combined with calcium antagonist has a good effect on elderly patients with coronary heart disease and high safety.