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目的建立兔眼球结膜微循环障碍模型，观察复方珍珠滴眼液（ＭＭＨ）对微循环障碍模型的作用，评价ＭＭＨ改善微循环障碍的可能性。方法采用兔耳静脉注射高分子右旋糖苷的方法建立兔眼球结膜微循环障碍模型。模型组的微循环障碍形成后点用０．９％氯化钠液；ＭＭＨ点眼组（实验组）分别点用对质量浓度及低质量浓度的ＭＭＨ。采用微循环图像处理系统对形态积分、流态积分、毛细血管袢周积分、总积分进行自动分析处理。结果ＭＭＨ对正常兔眼球结膜单次点眼具有增加毛细血管交叉点数、增加血流速度的功效。模型组与ＭＭＨ实验组相比，在形成微循环障碍严重程度方面差异显著。结论用高分子右旋糖苷建立兔眼球结膜微循环障碍模型成功。 ＭＭＨ具有预防微循环障碍的作用。
Objective To establish a model of microcirculation disturbance in rabbit eye conjunctiva and observe the effect of compound pearl eye drops (MMH) on the model of microcirculation disturbance and evaluate the possibility of MMH improving microcirculation disturbance. Methods Rabbit ocular conjunctival microcirculation disturbance model was established by injecting dextran with rabbit ear vein. The formation of microcirculation model points with 0.9% sodium chloride solution; MMH eye group (experimental group), respectively, point to mass concentration and low concentration of MMH. The microcirculation image processing system is used to automatically analyze and process morphological integrals, fluid integrals, capillaries weekly integrals and total integrals. RESULTS: MMH had the effect of increasing the blood flow velocity by increasing the number of capillaries crossing the eyeball of normal rabbit eye conjunctiva. Compared with the MMH experimental group, the model group showed significant differences in the severity of microcirculation impairment. Conclusion High molecular dextran was used to establish the model of microcirculation disturbance in rabbit eyes. MMH has the effect of preventing microcirculation disorders.