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经皮释药并非新概念,但治疗上迄今仅限于霜剂和软膏.70年代后期,研制出了一种能精确定量的经皮释药多部件装置.这是一种皮肤贴剂,能控制药物的释放速率,从而引起人们广泛的兴趣.本文介绍市售的经皮释药装置,并展望其未来.药物的选择和经皮控制释药的优点每一经皮制剂剂量的确定都以该药的物理化学、药动学、药效学特性为基础.一种药物必须具有能使血液循环中达到足够治疗浓度的皮肤渗透率.所需要的剂量越小亦越可能达到治疗水平.10mg/d的给药量通常被认为是经过吸收的上限.在一定渗透率下,经皮系统的有效面积决定了释入体内的剂量,利用面积和剂量的关系就可提供各种不同的给药量.经皮释药的特点在于避开了肝脏首过代谢,因此特别适用于主要在肝脏代谢而半
Transdermal drug delivery is not a new concept, but treatment has hitherto been limited to creams and ointments. In the late 1970s, a precise, quantitative transdermal drug delivery multi-component device was developed that is a skin patch that controls The rate of drug release has led to widespread interest.This article describes a commercially available transdermal delivery device and looks to its future.Medical Choice and Advantages of Transdermal Drug Release The dosage of each transdermal formulation is determined with this drug Based on physico-chemical, pharmacokinetic, pharmacodynamic properties, a drug must have sufficient skin permeability to achieve adequate therapeutic concentrations in blood circulation, and the smaller the dose required, the more likely it is to reach therapeutic levels.10 mg / d Is usually considered to be the upper limit of absorption.At a certain penetration rate, the effective area of the transdermal system determines the dose released into the body, the use of area and dose relationship can provide a variety of different doses. Transdermal drug delivery is characterized by the first pass to avoid the liver metabolism, it is particularly suitable for metabolism in the liver and half