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血管内皮生长因子(VEGF)是血管新生过程中一种重要的因子,在骨髓增生异常性疾病中起重要作用,其主要通过与受体(VEGFR)结合而发挥生物效应。改变骨髓或血浆中VEGF或VEGFR的水平可能成为治疗骨髓增生异常性疾病的新途径,本文就VEGF与骨髓增生异常性疾病的研究现状作一综述。
Vascular endothelial growth factor (VEGF) is an important factor in the process of angiogenesis and plays an important role in myelodysplastic diseases. It mainly exerts biological effects by binding with receptor (VEGFR). To change the level of VEGF or VEGFR in bone marrow or plasma may be a new way to treat myelodysplastic diseases. In this review, the current status of VEGF and myelodysplastic diseases is reviewed.