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据报告,20％以上的丙型肝炎病毒感染的病人会转为慢性肝病。本文作者利用1948年至1954年期间收藏储存的8568份原用于研究A组链球菌的血清标本,来确定丙型肝炎病毒感染的自然史。作者采用酶联免疫法和重组免疫印迹试验对8568份标本进行检测,发现有17份标本的丙型肝炎病毒抗体阳性(占2％)。 45年以后,在这17例丙型肝炎病毒抗体阳性的病人中,有2例(11.8％)被诊断为肝病,7例死亡(占41％),其中1人死于肝病,5人死于其它疾病,
It is reported that more than 20% of patients infected with hepatitis C virus will be converted to chronic liver disease. The authors used a total of 8,568 serum samples collected from 1948 to 1954 for the study of group A streptococci to determine the natural history of hepatitis C virus infection. The authors used enzyme-linked immunosorbent assay and recombinant immunoblotting to test 8,568 specimens and found 17 (75%) positive for hepatitis C virus antibodies (2%). Forty-five years later, out of 17 patients with positive hepatitis C virus antibodies, 2 (11.8%) were diagnosed with liver disease and 7 died (41%), 1 of whom died of liver disease and 5 died of Other diseases,