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目的:探讨丁胺卡那霉素与头孢拉定治疗小儿支气管肺炎对肾小管功能的影响。方法:将55例支气管肺炎患儿分成4组,分别用不同抗生素配伍治疗,并测定其尿中β_2微球蛋白含量。结果:丁胺卡那霉素+头抱拉定与其它几种抗生素配伍联合应用相比,尿β_2微球蛋白含量升高有显著差异。结论:头孢拉定确能加重丁胺卡那霉素对肾小管功能的损害,建议作这样的药物配伍要慎重,以避免加重对患儿肾功能的损害。
Objective: To investigate the effect of amikacin and cefradine on bronchial tube function in children with bronchopneumonia. Methods: Fifty-five children with bronchial pneumonia were divided into four groups and treated with different antibiotics. The content of β-microglobulin in urine was determined. Results: Compared with the combination of other antibiotics, the amikacin + cefradine markedly increased the urinary β 2 microglobulin content. Conclusion: Cefradine does aggravate the damage of renal tubular function induced by amikacin. It is suggested that such drug compatibility should be cautious to avoid aggravating the renal function impairment in children.