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1目的探讨糖尿病足病(DF)患者血清铁蛋白(SF)含量变化及两者之间的关系。2方法选取2型糖尿病患者138例,根据是否合并DF分为两组:糖尿病足病变组(DF组)和非糖尿病足病变组(DM组),各69例;另选取69例健康体检者作为对照组。使用电化学发光法检测所有受试对象的SF含量,并利用全自动生化分析仪测定其他各项生化指标。3结果 DF组、DM组和对照组血清SF含量分别为(625.75±65.31)、(458.98±46.76)、(278.65±38.35)ng/mL。DF组的SF较DM组和对照组均明显升高,差异有统计学意义(P<0.05);SF水平与糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均呈正显著相关(r=0.43、0.49、0.51、0.33,P<0.01)。Logistic回归分析示SF是DF的危险因素。4结论 SF含量升高与DF的发生发展密切相关,可以作为检测DF危险性的一个生化指标。
1 Objective To investigate the changes of serum ferritin (SF) in patients with diabetic foot disease (DF) and their relationship. 2 Methods 138 patients with type 2 diabetes were divided into two groups according to whether they were complicated with DF or not: DF group (DF group) and non-diabetic foot group (DM group), 69 cases each; 69 cases were selected as healthy subjects Control group. The content of SF in all the test subjects was detected by electrochemiluminescence. All other biochemical parameters were measured by automatic biochemical analyzer. 3 Results The serum SF levels of DF group, DM group and control group were (625.75 ± 65.31), (458.98 ± 46.76) and (278.65 ± 38.35) ng / mL, respectively. The SF of DF group was significantly higher than that of DM group and control group (P <0.05). SF levels were positively correlated with HbA1c, triglyceride (TG), total cholesterol (TC), low density The levels of serum lipoprotein cholesterol (LDL-C) were positively correlated (r = 0.43,0.49,0.51,0.33, P <0.01). Logistic regression analysis showed that SF was a risk factor for DF. 4 Conclusions The increase of SF content is closely related to the occurrence and development of DF, which can be used as a biochemical index to detect the risk of DF.