胰岛素依赖性糖尿病(IDDM)患者在病后第二个十年约有1/3出现糖尿病肾病,原因未明。晚近认为这种合并症多见于有高血压家族史的患者。糖尿病肾病患者往往伴血压升高,因而推断与肾损害有关。约25%患者有肾血流动力学异常,导致病程早期就发生肾小球滤过率和肾血浆流量增加。某些原发性高血压病患者,其红细胞钠-钾逆转运升高。在血压正常者,当其钠-钾逆转运活性增加会预示发生高血压。有报告 IDDM 和肾病患者的钠-钾逆转运升高,提示糖尿病肾病易发生,尤其是糖尿病 About 1% of patients with insulin-dependent diabetes mellitus (IDDM) develop diabetic nephropathy in the second decade after the illness, for unknown reasons. Recently think that this complication more common in patients with a family history of hypertension. Patients with diabetic nephropathy are often associated with elevated blood pressure, which is inferred to be associated with renal damage. About 25% of patients have abnormal renal hemodynamics, leading to an early onset of glomerular filtration rate and renal plasma flow increased. Some patients with essential hypertension, erythrocyte sodium-potassium reverse transport increased. In normotensives, an increase in its sodium-potassium reverse translocation activity predicts high blood pressure. There are reports of IDDM and renal disease in patients with sodium-potassium reverse transport increased, suggesting that diabetic nephropathy prone, especially diabetes