流行病学设想发现高密度指蛋白(HDL)水平降低和冠状动脉粥样硬化的发病之间有相关性,Helsinki 心脏研究所已发现 HDL 水平升高可以减少心肌梗死(致死性和非致死性)的发作。以前研究认为其理论基础是 HDL 减少胆固醇转运。最近数据表明 HDL 还具有抗血凝.稳定前列环素等有益的血管活性作用。并可以显著促进血管内皮细胞的增殖。近来认为血清胆固醇升高和乙酰胆碱(内皮依赖性血管扩张剂)的血管异常收缩使有关。本文企图通过检测血浆指蛋白与酰胆碱对人冠状动脉直径(由血管造影测定)作用的关系研究 HDL 胆固醇和冠状血管内皮功能的关系。 Epidemiologic findings have found a correlation between a decrease in high-density finger protein (HDL) levels and the incidence of coronary atherosclerosis. The Helsinki Heart Institute has found that elevated HDL levels can reduce myocardial infarction (fatal and non-fatal) The attack. Previous studies suggested that its rationale was HDL to reduce cholesterol transport. Recent data suggest that HDL also has beneficial antihypertensive effects such as stabilizing prostacyclin. And can significantly promote the proliferation of vascular endothelial cells. Recently, it is thought that the increase of serum cholesterol is related to the abnormal contraction of blood vessels of acetylcholine (endothelium-dependent vasodilator). This paper attempts to examine the relationship between HDL cholesterol and coronary endothelial function by measuring the relationship between plasma protein fingers and acetylcholine on human coronary artery diameter measured by angiography.