第四级铵氢氧化物的热消除反应并不都遵循Hofmann规则,为此文献(2)提出了一个消除反应的构象规则,为了检验这两个规则的适应性和可靠性,本文研究了八个可用于对比的第四级铵氢氧化物的热消除反应,结果表明构象规则远比经典的Hofmann规则优越。 The heat elimination reaction of the fourth grade ammonium hydroxide did not all follow the Hofmann rule. Therefore, a conformation rule eliminating the reaction was proposed in the literature (2). In order to test the adaptability and reliability of the two rules, The heat-elimination reactions of the fourth-stage ammonium hydroxide that can be used for comparison show that the conformational rules are far superior to the classical Hofmann’s rule.