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一系列芳香族和杂环化合物对乏氧细胞的辐射敏化效率主要与它们的电子亲和性有关。体外培养的哺乳动物细胞的敏化作用可用结构-活性关系来分析: -logC=b_0+b_1E_7~++b_2logP式中C为产生一定敏化作用所需要的化合物浓度,E_7~1为该化合物的单电子还原电位,P为该化合物在辛醇和水中的分配系数,b_0、b_1和b_2为常数。研究表明,亲电子项E_7~1是影响受照射的体外培养乏氧中国仑鼠细胞敏化效率的主要因子,而一系列类似敏化剂在含
The radiosensitization efficiency of a series of aromatic and heterocyclic compounds on hypoxic cells is mainly related to their electron affinity. Sensitization of mammalian cells cultured in vitro can be used to analyze the structure-activity relationship: -logC = b_0 + b_1E_7 ~ ++ b_2logP where C is the concentration of the compound required to produce a sensitizing effect, E_7 ~ 1 is the compound The single electron reduction potential, P is the partition coefficient of the compound in octanol and water, b_0, b_1 and b_2 are constants. The results showed that the electrophile E_7 ~ 1 was the main factor affecting the sensitization efficiency of Chinese rat murine cells exposed to irradiation, and a series of similar sensitizers