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目的探讨同时性双侧原发性乳腺癌(sBPBC)的病因、危险因素及预后。方法回顾性分析10例sBPBC患者的临床病理特征和生存结果。结果 10例患者,随访2-60个月,2例失访,1例死亡。患者多于绝经前发病,发病中位年龄为51.8岁;一半患者具有乳腺癌家族史。病理分期以Ⅰ、Ⅱ期肿瘤为主,双侧病灶中ER、PR和HER2表达的一致性较高,p53表达的一致性稍有差异。结论 sBPBC的危险因素包括年龄较轻、尚未绝经及有乳腺癌家族史等。与异时性双侧原发性乳腺癌(mBPBC)和转移性双侧乳腺癌相比,sBPBC双侧病灶的分子生物学特征更加相似,患者的预后及生存率与两侧病灶中分期较重的一侧相关。
Objective To investigate the etiology, risk factors and prognosis of simultaneous bilateral primary breast cancer (sBPBC). Methods The clinicopathological features and survival of 10 patients with sBPBC were retrospectively analyzed. Results 10 patients were followed up for 2-60 months, 2 were lost and 1 died. More patients than pre-menopausal onset, the median age of onset was 51.8 years; half of patients with a family history of breast cancer. The pathological staging was mainly stage I and II tumors. The consistency of the expression of ER, PR and HER2 in bilateral lesions was high, and the consistency of p53 expression was slightly different. Conclusion The risk factors of sBPBC include younger age, not yet menopause and family history of breast cancer. Compared with mBPBC and metastatic breast cancer, the molecular biological features of bilateral sBPBC lesions are more similar, and the prognosis and survival rate of patients with sBPBC are higher than that of the bilateral lesions Related to one side.