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本工作用家兔做急性实验发现:(1)侧脑室注射氯化钙(500微克/100微升),可使动脉血压显著降低,5、30、60分钟时分别降低10％、45％、60％。(2)侧脑室注射纳络酮(100微克/100微升)可部分翻转钙离子的降压效应。(3)侧脑室注射异搏停(250微克/100微升)也可抵消钙离子的降压效应。这些实验结果提示,中枢鸦片样物质对钙离子的降压效应具有一定作用;应用钙拮抗剂阻止钙内流或采取一切中枢降钙措施,可能有助于防治休克的低血压。
In this study, rabbits were subjected to acute experiment and found that: (1) intracerebroventricular injection of calcium chloride (500 microg / 100 microliters) significantly reduced arterial blood pressure and decreased 10%, 45% 60%. (2) Intracerebroventricular administration of naloxone (100 μg / 100 μl) partially reversed the antihypertensive effects of calcium. (3) intraventricular injection of verapamil (250 micrograms / 100 microliters) can also offset the antihypertensive effect of calcium. These experimental results suggest that the central opioid substance has a certain effect on the antihypertensive effects of calcium ion. The use of calcium antagonists to prevent calcium influx or to take all central calcium-lowering measures may help prevent and control hypotensive hypotension.