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氧化吲哚是一类重要的杂环,广泛存在于具有生物活性的天然产物和药物分子中.近年来,利用邻位无取代的N-芳基丙烯酰胺为原料,通过包含有芳烃C-H官能化的烯烃双官能化进行环化获得氧化吲哚的途径由于有原料简单易得、反应原子经济性高、能将各种类型的基团引入氧化吲哚结构等特点而备受关注.本文主要根据不同的反应机理及反应体系类型分类对该领域的研究进行综述.
Oxindole is an important class of heterocycles, which are widely found in biologically active natural products and drug molecules. In recent years, using ortho-substituted N-aryl acrylamides as starting materials, Of the olefin bifunctional cyclization to obtain the method of oxidation of indole due to simple and readily available raw materials, high economic atom of the reaction, can all kinds of groups into the structure of the oxidation of indole and other characteristics of much attention.This article mainly based on Different reaction mechanism and reaction system type classification are reviewed in this field.