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目的研究胰岛素样生长因子Ⅰ(IGF-Ⅰ)对糖尿病大鼠拔牙后牙槽骨改建的影响,为糖尿病性牙周病的治疗提供依据。方法对四氧嘧啶诱导的糖尿病大鼠拔牙后进行胰岛素和胰岛素样生长因子Ⅰ治疗,通过X线、组织切片苏木精-伊红染色和四环素双标记的方法观察牙槽骨改建情况。结果与正常组相比,糖尿病大鼠拔牙创骨愈合减慢,骨形成减少,牙槽骨高度和牙槽骨骨形成率显著降低。IGF-Ⅰ的治疗不仅能控制糖尿病大鼠的血糖保持在正常范围内,还可以增加牙槽骨高度和提高骨形成率。结论IGF-Ⅰ的治疗可以促进糖尿病大鼠拔牙创骨愈合和增加骨形成量,且与胰岛素治疗之间没有明显差别。
Objective To investigate the effect of insulin-like growth factor-Ⅰ (IGF-Ⅰ) on alveolar bone remodeling after tooth extraction in diabetic rats, and provide evidence for the treatment of diabetic periodontal disease. Methods Alloxan - induced diabetic rats were treated with insulin and insulin - like growth factor Ⅰ after tooth extraction. The reconstruction of alveolar bone was observed by X - ray and histological sections with hematoxylin - eosin staining and tetracycline double labeling. Results Compared with the normal group, the healing of the tooth in diabetic rats was slowed down, the bone formation was reduced, the alveolar bone height and alveolar bone formation rate were significantly decreased. IGF-Ⅰ treatment can not only control the blood glucose in diabetic rats remain within the normal range, but also can increase the alveolar bone height and increase the rate of bone formation. Conclusion IGF-Ⅰ treatment can promote bone healing and increase the amount of bone formation in diabetic rats with tooth extraction, and there is no significant difference between insulin treatment.