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目的:探讨18F-氟化脱氧葡萄糖(18 F-FDG)与11 C-胆碱PET-CT联合应用在肺部占位性病变鉴别诊断中的价值。方法:选取196例肺部占位性病变患者,注射造影剂18F-FDG和11 C-胆碱后行PET-CT检查和诊断,观察2种造影剂PET-CT检查方法的标准摄取值(SUV)以及单独和联合应用的诊断灵敏度、特异性和准确率。结果:良性和恶性患者的18F-FDG(2.20±1.23 vs 5.29±2.75)及11 C-胆碱(0.81±0.79 vs 3.28±1.76)的SUVmax差异有统计学意义,P<0.01;18F-FDG和11 C-胆碱在良性及恶性患者中差异有统计学意义,P<0.01。18 F-FDG和11 C-胆碱PET-CT各自的灵敏度(58.16%vs 58.67%)、特异性(78.05%vs 84.00%)和准确率(80.61%vs 85.20%)差异无统计学意义,P>0.05。联合诊断的灵敏度、特异性和准确率分别为53.57%(105/196)、90.11%(82/91)和94.39%(185/196),与单独应用比较,灵敏度差异无统计学意义(P>0.05),特异性和准确率均提高,P<0.01。结论:将18 F-FDG和11 C-胆碱PET-CT检查联合运用于同一患者进行综合诊断能明显提高肺部占位病变的诊断水平。
Objective: To investigate the value of 18F-fluorodeoxyglucose (18 F-FDG) combined with 11 C-choline PET-CT in the differential diagnosis of pulmonary space-occupying lesions. Methods: One hundred and sixty-six patients with lung space-occupying lesions were selected. The contrast-enhanced PET-CT scans of 18F-FDG and 11C-choline were performed. The standard values of two contrast media PET-CT examinations ) As well as the diagnostic sensitivity, specificity and accuracy of the individual and combined use. Results: There was significant difference in SUVmax between 18F-FDG (2.20 ± 1.23 vs 5.29 ± 2.75) and 11C-choline (0.81 ± 0.79 vs 3.28 ± 1.76) in benign and malignant patients, P <0.01; 18F-FDG and 11 C-choline had statistically significant difference between benign and malignant patients, P <0.01.18 The sensitivity (58.16% vs 58.67%) and specificity (78.05%) of F-FDG and 11- vs 84.00%) and the accuracy (80.61% vs 85.20%) was not statistically different (P> 0.05). The sensitivity, specificity and accuracy of the combined diagnosis were 53.57% (105/196), 90.11% (82/91) and 94.39% (185/196), respectively. There was no significant difference in sensitivity between the two groups (P> 0.05), specificity and accuracy were increased, P <0.01. Conclusions: Combined use of 18 F-FDG and 11 C-choline PET-CT in the same patient can significantly improve the diagnosis of lung space occupying lesion.