论文部分内容阅读
目的探讨降钙素原(PCT)检测在新生儿败血症的早期诊断及治疗中的应用。方法回顾性分析2013年7月-2015年7月该院治疗新生儿败血症患儿50例,取同时期支气管肺炎患儿50例为感染组,再选取同时期的健康新生儿50例作为对照组,对比3组新生儿PCT、hs-CRP、WBC三项指标。结果败血症组新生儿的PCT数值明显高于感染组和对照组,差异有统计学意义(P<0.05),而hs-CRP、WBC与感染组比较无明显差异(P>0.05)。败血症组hs-CRP及WBC均高于对照组,差异均有统计学意义(P<0.05)。败血症组新生儿PCT阳性率明显高于hs-CRP、WBC的阳性率,感染组新生儿PCT阳性率低于hs-CRP、WBC的阳性率,差异均有统计学意义(P<0.05)。败血症组新生儿的在治疗第7天后PCT、WBC指标下降至正常范围,而hs-CRP指标则仍明显高于正常。结论 PCT诊断新生儿败血症的早期诊断指标敏感性、特异性均较高,可作为临床诊断、疗效监测中的一项重要指标。
Objective To investigate the application of procalcitonin (PCT) in the early diagnosis and treatment of neonatal sepsis. Methods From July 2013 to July 2015, 50 children with neonatal sepsis were treated in our hospital from July 2013 to July 2015. Fifty children with bronchopneumonia in the same period were selected as the infected group. Fifty healthy newborns in the same period were selected as the control group , Comparing three groups of neonatal PCT, hs-CRP, WBC three indicators. Results The PCT value of newborn infants in sepsis group was significantly higher than that in infection group and control group (P <0.05). There was no significant difference between hs-CRP and WBC in infection group (P> 0.05). The serum levels of hs-CRP and WBC in sepsis group were significantly higher than those in control group (P <0.05). The positive rate of PCT in neonates with sepsis was significantly higher than that of hs-CRP and WBC. The positive rate of PCT in neonates with infection was lower than that of hs-CRP and WBC (P <0.05). In the sepsis group, the PCT and WBC index decreased to the normal range on the 7th day after treatment, while the hs-CRP index was still significantly higher than normal. Conclusion PCT diagnosis of neonatal sepsis early diagnostic indicators sensitivity and specificity are high, as an important indicator of clinical diagnosis, efficacy monitoring.