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以往的研究表明,肠道传播的非甲非乙型(ENANB)肝炎患者粪便中可检测到戊型肝炎病毒(HEV),血清中也可查到抗戊型肝炎病毒抗体(抗-HEV),但尚未在肝脏中发现HEV颗粒。作者应用电境、免疫电镜等技术在1例死于暴发性肝炎的患者肝脏中检测到HEV颗粒。患者女性,20岁,怀孕6个月,昏迷入院。7天前有发烧、呕吐和上腹痛。无输血史。呈深度黄疸,肝脾未触及,淋巴结不肿大。总胆红素(TB)298μmol/L,凝血酶原时间(PT)26秒。入院第6天,TB226μmol/L,PT62秒。第11天早产,产后大出血,随后很快死亡。入院第5天时检查,血清HBsAg、
Previous studies have shown that hepatitis E virus (HEV) can be detected in the stool of patients with enterally transmitted non-A, B (ENANB) hepatitis and that anti-HEV antibodies (anti-HEV) However, HEV particles have not yet been found in the liver. The authors applied electric field and immunoelectron microscopy to detect HEV particles in the liver of a patient who died of fulminant hepatitis. Female patient, 20 years old, 6 months pregnant, coma admitted. 7 days ago with fever, vomiting and abdominal pain. No blood transfusion history. Was deep jaundice, liver and spleen not touched, lymph nodes are not swollen. Total bilirubin (TB) 298 μmol / L, prothrombin time (PT) 26 seconds. On admission day 6, TB226μmol / L, PT62 seconds. Preterm delivery on day 11, postpartum hemorrhage, and subsequent death soon. On the 5th day of hospitalization, serum HBsAg,