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１９８９年３月至１９９１年１月，作者将经病理诊断且为初治的１６７例Ⅲ、Ⅳ期鼻咽癌病人，随机分为单纯放疗组和综合治疗组（放疗后加ＣＯＢ方案化疗），进行疗效对比。结果：单纯放疗组８８例的５年生存率为３０．７％，综合治疗组７９例为４０．５％；两个治疗组中的Ⅲ期病人，分别为３８．９％和５２．０％（Ｐ＞０．０５）；两组原发灶及颈淋巴结复发率，复发中位时间基本相同；两组Ⅲ期病人的远处转移发生率分别为２４．０％及３３．３％（Ｐ＞０．０５）；出现远处转移的中位时间，综合组比单纯放疗组延迟（Ｐ＜０．０５）；两组患者的主要死亡原因为复发和转移，两组死亡病例的中位生存期，综合组长于单纯放疗组（Ｐ＜０．０５）；远期后遗症的发生率，综合组高于单纯放疗组（Ｐ＜０．０１）。
From March 1989 to January 1991, 167 patients with stage III and IV nasopharyngeal carcinoma, which were pathologically diagnosed and treated as initial treatment, were randomly divided into radiotherapy group and comprehensive treatment group (COB chemotherapy after radiotherapy) To compare the efficacy. Results: The 5-year survival rate of 88 patients in the radiotherapy group was 30.7%, while that in the comprehensive treatment group was 40.5%. The patients in the two treatment groups were 38.9% and 52.0% respectively, (P> 0.05). The recurrence rate and recurrence time of the primary tumor and cervical lymph node in both groups were basically the same. The incidence of distant metastasis in stage Ⅲ patients of two groups were respectively 24.0% and 33.3% (P > 0.05). The median time to distant metastasis was longer in the combined group than in the radiotherapy alone group (P <0.05). The main causes of death were recurrence and metastasis in both groups, with the median survival of the two groups (P <0.05). The incidence of long-term sequelae in the combined group was higher than that of the radiotherapy alone group (P <0.01).