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观察了减压缺氧不同时间Ｗｉｓｔａｒ大鼠肺腺泡内动脉中膜平滑肌细胞（ＳＭＣ）表型情况。主要发现：（１）缺氧３～４０ｄ组，肺动脉压（ＰＡＰ）持续显著升高，右心肥厚程度逐渐加重。（２）缺氧１～５ｄ组，中膜ＳＭＣ仍为收缩表型，胞间胶原分布略有所增加；缺氧７ｄ组，于近内弹力层处少数ＳＭＣ转变为合成表型，还有些细胞向合成表型部分转化，胞间胶原增多；缺氧１４～４０ｄ组，与合成分泌功能有关细胞器及胶原分布仍较缺氧１～５ｄ组ＳＭＣ为多，少数ＳＭＣ仍呈部分合成表型，大多数ＳＭＣ又出现收缩表型的特征。提示：随缺氧时间延长，ＩＡＡ中膜ＳＭＣ表型可能存在动态变化，但与ＰＡＰ的变化不呈平行关系。原因有待探讨。
The phenotypes of medullary smooth muscle cells (SMCs) in the pulmonary alveoli of Wistar rats were observed at different time points after hypobaric hypoxia. The main findings were as follows: (1) Pulmonary arterial pressure (PAP) increased significantly in hypoxia 3 ~ 40 d group, and right ventricular hypertrophy gradually increased. (2) In the 1 ~ 5d hypoxia group, the SMC in the tunica media was still a contractile phenotype with a slight increase in the distribution of intracellular collagen. In the hypoxia group 7d, a few SMCs were transformed into the synthetic phenotype in the near-end elastic layer, and some cells Some hypoxia SMC were still more than those in hypoxia for 1 ~ 5 days, and some SMCs still showed some synthetic phenotype, large The majority of SMC contractions phenotype characteristics. It is suggested that there may be a dynamic change of SMC phenotype in IAA with the prolongation of hypoxia, but not with the change of PAP. The reason to be discussed.