先天性多形角化病在 Touraine(1954)给予命名以前,文献上早已有类似疾病报导,但其命名繁多、概念混乱。自从Touraine 提出此一综合征的论述后,始使人们对本病有了一个较为清晰的认识。按照Touraine 所述:本病系一先天性全身性疾病,其临床特点为: 1.皮肤粘膜角化病:(1)掌蹠角化病; Congenital polymorphous keratosis Before the name was given by Touraine (1954), there was a long history of similar diseases in the literature, but its name was numerous and the concept was confusing. Since Touraine’s presentation of this syndrome, it has led to a clearer understanding of the disease. According to Touraine: The disease is a congenital systemic disease, its clinical features are: 1. Skin and mucosal keratosis: (1) palmoplantar keratosis;