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基因特别是抑癌基因启动子区CpG岛甲基化与非小细胞肺癌(NSCLC)发生发展关系的研究正受到越来越多的重视。本研究用甲基化特异性的PCR(MSP)测NSCLC细胞株中12个肿瘤相关基因的甲基化发生情况,并观察甲基化与mRNA转录之间的关系,以进一步阐明抑癌基因甲基化在NSCLC中的作用。一
Genes, especially CpG island methylation in tumor suppressor gene promoter region and development of non-small cell lung cancer (NSCLC) are receiving more and more attention. In this study, methylation-specific PCR (MSP) was used to detect the methylation of 12 tumor-associated genes in NSCLC cell lines and to observe the relationship between methylation and mRNA transcription to further elucidate the tumor suppressor gene A The role of methylation in NSCLC. one