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以往研究提示，ｃ－ｍｙｃ和ｃ－ｅｒｂＢ－２癌基因在鼻咽癌中有过表达．为了阐明这两种癌基因过表达的分子机制，应用当前肿瘤研究新技术──组织微阵列，结合间期双色荧光原位杂交（ＦＩＳＨ）和免疫组化（ＩＨＣ），对２６７例鼻咽癌组织、２４例癌旁组织和２９例鼻咽部慢性炎症组织进行了大样本研究．结果发现，鼻咽癌ｃ－ｍｙｃ和ｃ－ｅｒｂＢ－２癌蛋白过表达发生率分别为４８％～６３％和２０％～３８％；但ｃ－ｍｙｃ和ｃ－ｅｒｂＢ－２两个癌基因在鼻咽癌中均无扩增；８与１７号着丝粒探针杂交则分别显示有４３％～５０％和２０％～２７％的鼻咽癌染色体呈现多体性． 蛋白表达分析表明，ｃ－ｅｒｂＢ－２表达与１７号染色体多体性有关（Ｐ＜０．０００５）．
Previous studies suggest that c-myc and c-erbB-2 oncogenes are overexpressed in NPC. To elucidate the molecular mechanism of overexpression of these two oncogenes, 267 nasopharyngeal carcinomas (NPCs) were treated with novel microarray technology combined with interphase two-color fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) 24 cases of paracancerous tissues and 29 cases of nasopharyngeal chronic inflammatory tissues were studied in a large sample. The results showed that the over-expression rates of c-myc and c-erbB-2 oncogene in nasopharyngeal carcinoma were 48% -63% and 20% -38%, respectively. However, the two oncogenes of c-myc and c-erbB- There was no amplification in nasopharyngeal carcinoma; hybridization of the centromere probe with chromosome 17 and 17 showed 43% ~ 50% and 20% ~ 27% of nasopharyngeal carcinoma chromosomes showed polycythemia. Protein expression analysis showed that the expression of c-erbB-2 was associated with the polymorphism of chromosome 17 (P <0.0005).