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骨量的维持依赖于骨再建过程,即骨形成和骨吸收的动态平衡。该过程受调节骨代谢的激素和细胞因子共同组成的复杂网络的精密调节。破骨细胞是实现骨吸收的效应细胞,其形成、分化、激活和凋亡的净结果决定着破骨细胞池的大小,进而决定着骨吸收的速率和程度。破骨细胞的形成和分化是进行骨吸收的前提。破骨细胞前体只有在与骨髓基质细胞或成骨细胞共培养时,才会成熟、分化,并造成骨吸收,而纯化的破骨细胞谱系不能进行骨吸收。1L-1、IL-6、TNF、IL-11等细胞因子和1,25(OH)_2 D_3、PTH等趋钙激素
The maintenance of bone mass depends on the process of bone remodeling, the dynamic balance of bone formation and bone resorption. The process is closely regulated by a complex network of hormones that regulate bone metabolism and cytokines. Osteoclasts are effector cells for bone resorption. The net result of their formation, differentiation, activation and apoptosis determines the size of the osteoclast pool, which in turn determines the rate and extent of bone resorption. The formation and differentiation of osteoclasts is a prerequisite for bone resorption. Osteoclast precursors mature, differentiate, and cause bone resorption only when co-cultured with bone marrow stromal cells or osteoblasts, whereas purified osteoclast lineages can not undergo bone resorption. 1L-1, IL-6, TNF, IL-11 and other cytokines and 1,25 (OH) _2 D_3, PTH and other calcium-promoting hormone