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目的探讨前列腺小细胞癌的临床、病理特征及治疗方法。方法回顾性分析3例前列腺小细胞癌患者的临床资料并复习文献。结果2例术后病理诊断为前列腺小细胞癌,1例经直肠穿刺活检示前列腺小细胞癌,切片见肿瘤呈弥漫性片、巢状结构,伴大片凝固性坏死。核小、燕麦状或圆形、染色深、核仁不明显、胞质少,类似肺小细胞癌。例1行免疫组化染色检查:LCA、L-26、34βE12、P504s(-),PSA、AE1/AE3、AR(+),CA、S-100(±)。例1术后3个月死于全身广泛转移,例2术后13个月死于肺转移,例3术后5个月,仍在随访中。结论前列腺小细胞癌是一种少见的高度恶性的肿瘤,确诊主要依靠病理诊断,早期即可发生转移,预后较差。目前尚无较满意的治疗方法。
Objective To investigate the clinical, pathological features and treatment of prostatic small cell carcinoma. Methods Retrospective analysis of 3 cases of small cell carcinoma of the prostate in patients with clinical data and review the literature. Results Two cases were diagnosed as small cell carcinoma of the prostate (PCC) by pathology and one case of small cell carcinoma of the prostate by transnasal biopsy. The tumor showed diffuse and nested structure with large coagulation necrosis. Small nucleus, oat or round, deep staining, nucleoli are not obvious, less cytoplasm, similar to small cell lung cancer. Example 1 immunohistochemical staining: LCA, L-26,34βE12, P504s (-), PSA, AE1 / AE3, AR (+), CA, S-100 (±). Example 1 3 months after the operation died of extensive systemic metastases, Example 2 died of lung metastasis 13 months after the operation, Example 3 5 months after the operation is still under follow-up. Conclusion Small cell carcinoma of the prostate is a rare and highly malignant tumor. The diagnosis mainly depends on the pathological diagnosis. The small cell carcinoma of the prostate can metastasize early and the prognosis is poor. At present there is no more satisfactory treatment.