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采用酶联免疫法研究肺中Ⅰ型与Ⅲ型胶原含量,以比较不同矿尘所致肺纤维化程度。用此方法测定胶原含量比传统方法有快速、特异性强的优越性。矿尘是采自瑶岗仙钨矿现场和化学品金属氧化物如三氧化钨及二氧化锰。所得结果表明,矿尘中的金属如钨、锰、砷等本身均无明显促使肺胶原增生的作用;锡与铁有轻微的促进作用,矿浆与矿壁沉降尘的作用不明显。矿脉石英尘有较强的促进胶原增生作用,说明该矿粉尘的主要危害与矿尘中石英含量有关。
Enzyme-linked immunosorbent assay was used to study the content of type I and type III collagen in lungs to compare the degree of pulmonary fibrosis caused by different mineral dusts. Using this method to determine the collagen content than the traditional method has the advantages of rapid, specific and strong. Mine dust is collected from the site of Yao Gang cents tungsten and chemical metal oxides such as tungsten trioxide and manganese dioxide. The results showed that the metal dust in the mine dust such as tungsten, manganese, arsenic and so on itself did not significantly promote the proliferation of lung collagen; tin and iron have a slight role in promoting, mining and mining wall sedimentation effect is not obvious. Mineral quartz dust has a strong role in promoting collagen proliferation, indicating that the main hazards of mine dust and dust in the quartz content.