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亚临床型甲状腺功能减退症(亚临床甲减)较为常见,40岁以上女性发生率约为10%。本病一般概念为无临床症状。血清游离 T_4和总 T_4正常,但血清甲状腺刺激激素(TSH)升高,口服促甲状腺素释放激素(TRH)兴奋试验结果 TSH 反应增强。这种临床状态近年来被认为是冠心病的危险因素。目前对亚临床甲减状态下冠心病的发病机制争论颇多。亚临床甲减血脂测定结果文献报告不一,而血浆脂蛋白有何改变尚未见有报告。作者研究了亚临床甲减52例及临床型甲减18例,
Subclinical hypothyroidism (subclinical hypothyroidism) is more common, the incidence of women over the age of 40 is about 10%. The general concept of the disease is no clinical symptoms. Serum free T 4 and total T 4 normal, but serum thyroid stimulating hormone (TSH) increased, oral thyrotropin-releasing hormone (TRH) stimulation test results TSH response increased. This clinical status in recent years is considered a risk factor for coronary heart disease. At present there are many controversies about the pathogenesis of CHD in subclinical hypothyroidism. Subclinical hypothyroidism measured results of the literature reported different, but no change in plasma lipoprotein has been reported. The authors studied subclinical hypothyroidism in 52 cases and clinical hypothyroidism in 18 cases,