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目的探讨2型糖尿病(T2DM)患者下肢动脉内膜中层厚度(IMT)与超敏C反应蛋白(hs-CRP)及纤维蛋白原(Fg)的相关性。方法选取2010年1—12月在暨南大学第二临床学院内分泌科住院的T2DM患者89例作为T2DM组,选取同期体检中心的健康者85例作为对照组。收集临床资料〔包括年龄、性别、身高、血压(收缩压和舒张压)、腰围、臀围,计算体质指数(BMI)和腰臀比(WHR)〕;检测生化指标〔包括空腹血糖(FPG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、hs-CRP、Fg〕;彩超测量下肢动脉〔股动脉(CFA)及腘动脉(POA)〕IMT。采用Pearson线性相关分析下肢动脉IMT与hs-CRP及Fg的关系。结果两组收缩压和舒张压比较,差异无统计学意义(P>0.05);T2DM组患者的BMI和WHR均高于对照组(P<0.05)。两组TG、TC比较,差异无统计学意义(P>0.05);T2DM组患者的LDL-C、FPG、HbA1c均高于对照组,而HDL-C低于对照组(P<0.05)。T2DM组的hs-CRP、Fg、CFA IMT、POA IMT均高于对照组(P<0.05)。T2DM组患者CFA IMT与POA IMT呈正相关(r=0.461,P<0.05),CFA IMT与hs-CRP、Fg呈正相关(r=0.367、0.456,P<0.05),POA IMT与hs-CRP、Fg呈正相关(r=0.379、0.417,P<0.05)。结论 T2DM患者下肢动脉IMT与hs-CRP及Fg均呈正相关关系,动态监测hs-CRP及Fg有助于早期预测T2DM下肢动脉病变的发生发展,值得临床推广应用。
Objective To investigate the correlation between lower extremity arterial intima-media thickness (IMT) and high-sensitivity C-reactive protein (hs-CRP) and fibrinogen (Fg) in type 2 diabetes mellitus (T2DM) Methods Totally 89 T2DM patients hospitalized in Department of Endocrinology, School of Endocrinology, Second Clinical College of Jinan University from January to December in 2010 were selected as T2DM group. Totally 85 healthy subjects were selected as control group. Clinical data (including age, gender, height, blood pressure (systolic and diastolic blood pressure, waist circumference, hip circumference, body mass index (BMI) and WHR) were collected; biochemical markers, including fasting plasma glucose (FPG) , HbA1c, TG, TC, LDL-C, HDL-C, hs-CRP, Fg); color Doppler ultrasound Lower extremity arterial (femoral artery (CFA) and popliteal artery (POA)] IMT were measured. Pearson linear correlation analysis of lower extremity artery IMT and hs-CRP and Fg relationship. Results There was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups (P> 0.05). The BMI and WHR in T2DM group were significantly higher than those in control group (P <0.05). There was no significant difference between the two groups (P> 0.05). The levels of LDL-C, FPG and HbA1c in T2DM group were higher than those in control group, while HDL-C was lower than that in control group (P <0.05). The levels of hs-CRP, Fg, CFA IMT and POA IMT in T2DM group were higher than those in control group (P <0.05). CFA IMT was positively correlated with POA IMT (r = 0.461, P <0.05), CFA IMT was positively correlated with hs-CRP and Fg in T2DM patients (r = 0.367,0.456, P < (R = 0.379, 0.417, P <0.05). Conclusion IMT of lower extremity arteries in T2DM patients have a positive correlation with hs-CRP and Fg. Dynamic monitoring of hs-CRP and Fg may be helpful to predict the occurrence and development of arterial disease of lower extremities in T2DM. It is worthy of clinical application.