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目的探讨吸烟与血清高密度脂蛋白胆固醇(HDL-C)水平的相关性,分析吸烟量与血清HDL-C水平之间的量效关系。方法对5274例资料按照每日吸烟量分成7组,分别比较各吸烟量组与不吸烟组的血清HDL-C水平之间的差异,分析吸烟量与血清HDL-C水平之间的直线相关性,并求得直线回归方程。结果不吸烟组的HDL-C水平为1.43mmol/L,各吸烟量组的HDL-C水平均较不吸烟组低(P值均﹤0.0005)。每日吸烟1~5支者,与每日吸烟6~10支者HDL-C水平差异无统计学意义(P﹥0.05);每日吸烟量大于10支者,较吸烟量10支以内者HDL-C水平低,差异有统计学意义(P﹤0.001)。随着每日吸烟量的增加,血清HDL-C水平呈现下降趋势。HDL-C水平与吸烟量之间存在直线相关性(r=0.066,P﹤0.05),直线回归方程为Y=1.3118-0.0018x;对于吸烟且不饮酒者,直线回归方程为Y=1.3013-0.0019x(两方程回归系数检验,P值均﹤0.005)。结论 HDL-C水平与吸烟量之间存在直线相关性。HDL-C水平随着吸烟量的增加而降低。每日多吸一支烟,HDL-C水平降低约0.0018~0.0019mmol/L。吸烟习惯难以戒除者,最好将每日吸烟量控制在10支以内。
Objective To explore the relationship between smoking and serum high-density lipoprotein cholesterol (HDL-C) level and to analyze the relationship between smoking and serum HDL-C level. Methods The data of 5274 cases were divided into 7 groups according to their daily smoking volume. The differences of serum HDL-C levels between smoking groups and non-smoking groups were compared respectively. The linear correlation between smoking amount and serum HDL-C level , And get the linear regression equation. Results The level of HDL-C in non-smoker group was 1.43 mmol / L, and the HDL-C levels in all smoking groups were lower than those in non-smoker group (all P <0.0005). There was no significant difference in HDL-C levels between 1 and 5 cigarettes a day and 6 to 10 cigarettes per day (P> 0.05). Daily smoking was more than 10 cigarettes, while smoking was less than 10 HDL The level of C was low, the difference was statistically significant (P <0.001). With the increase of daily smoking, serum HDL-C levels showed a downward trend. There was a linear correlation between HDL-C level and smoking amount (r = 0.066, P <0.05), and the linear regression equation was Y = 1.3118-0.0018x. For smoking and non-alcohol consumption, the linear regression equation was Y = 1.3013-0.0019 x (two equation regression coefficient test, P <0.005). Conclusion There is a linear correlation between HDL-C level and smoking amount. HDL-C levels decrease as smoking increases. Smoking a day more smoke, HDL-C levels decreased by about 0.0018 ~ 0.0019mmol / L. Smoking habits hard to get rid of, it is best to control the amount of daily smoking within 10 or less.