论文部分内容阅读
胰腺癌的发病率近年来在世界各地有明显增高趋势,按人口统计其发病率约为每年10/10万,在老年人中高达每年100/10万。胰腺癌在西方国家的癌症病死率中排名第5,在所有较常见的癌症中5年存活率最低。尽管近年来胰腺癌的影像诊断技术有很大进步,但由于仍缺乏特异性较好的诊断标志物,胰腺癌的早期诊断及与慢性胰腺炎的鉴别仍是难题。许多近期研究显示,分子生物学变化在胰腺癌的发生发展过程中起着重要作用,其中黏蛋白基因的异常表达与胰腺癌密切相关,这为胰腺癌的早期诊断提供了可能。本文综述了黏蛋白基因的表达在胰腺癌发生发展过程中的意义。
The incidence of pancreatic cancer has shown a marked increase in recent years in various parts of the world. According to the statistics, the incidence of pancreatic cancer is about 10 million per year and as high as 100 per 100,000 per year among the elderly. Pancreatic cancer is ranked fifth in cancer death rates in western countries and has the lowest 5-year survival rate in all of the more common cancers. Although imaging diagnosis of pancreatic cancer has been greatly improved in recent years, the early diagnosis of pancreatic cancer and the identification of chronic pancreatitis are still difficult due to the lack of specific and specific diagnostic markers. Many recent studies have shown that molecular biological changes play an important role in the development of pancreatic cancer. The abnormal expression of mucin gene is closely related to pancreatic cancer, which may provide an early diagnosis of pancreatic cancer. This article reviews the significance of mucin gene expression in the development of pancreatic cancer.