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目的:了解不同海拔长期缺氧暴露对男性精子功能的影响。方法:以驻留海拔5340m1～3年的28例健康男性青年为高海拔组,以34例现驻平均海拔3800m2～5年的健康男性青年为中海拔组,对照组为31例常年生活在1300m海拔地区的成年男性。收集精液标本,采用计算机辅助精液分析系统(CASA)对精子参数进行分析。结果:高海拔组的精子密度、精子曲线运动速度(VCL)、直线运动速度(VSL)、平均路径速度(VAP)和直线性(LIN)分别为(51.12±14.61)×106/ml、(48.17±13.52)μm/s、(32.64±6.70)μm/s、(41.21±9.32)μm/s和(52.24±8.14)%,均明显低于对照组(P<0.01或P<0.05)。中海拔组的精子密度、精子活率、VSL、VCL、LIN、VAP和ALH等参数较对照组亦有不同程度的下降,但差异无显著性(P>0.05)。结论:随着海拔高度的增加,高原缺氧暴露对成年男性的精子参数的负面影响愈明显。
Objective: To understand the effect of long-term hypoxia exposure at different altitudes on sperm function in men. Methods: Twenty-eight healthy male youths resident at an elevation of 5340m1 to 3 years were in high altitude group. Among them, 34 healthy young men and women with an average elevation of 3800m2 to 5 years were mid-altitude group and 31 healthy adults in control group were at 1300m Adult male at altitude. Semen samples were collected and the sperm parameters were analyzed using the computer-assisted semen analysis system (CASA). Results: The sperm density, spermatic curve velocity (VCL), linear velocity (VSL), average path velocity (VAP) and linearity (LIN) were 51.12 ± 14.61 × 106 / ml and 48.17 ± 13.52μm / s, (32.64 ± 6.70) μm / s, (41.21 ± 9.32) μm / s and (52.24 ± 8.14)%, respectively, which were significantly lower than those in the control group (P <0.01 or P <0.05). The parameters of sperm density, sperm motility, VSL, VCL, LIN, VAP and ALH in middle altitude group also decreased to some extent compared with the control group, but the difference was not significant (P> 0.05). Conclusion: With the increase of altitude, the negative effect of plateau hypoxia exposure on adult sperm parameters is more obvious.