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为探讨喉癌下咽癌的发生与吸烟饮酒及染色体敏感性等因素的关系，对154例喉癌和下咽癌患者及107位正常人做病例对照研究。结果显示吸烟和饮酒者的患癌风险明显高于非吸烟饮酒者，患癌风险随烟酒用量的加大而增加。染色体对致突变剂的敏感性实验显示，每细胞染色单体断裂率（b／c值）是一反映机体对致突变物或致癌物敏感性的重要标志。以b／c值0．40为敏感值时，病例组中约80％高于此值，对照组中80％低于此值。根据研究结果我们认为喉癌下咽癌的发生主要由体质性因素所决定，喉癌和下咽癌患者是人群中对致癌物敏感性增高者再加上长期吸烟和饮酒等环境因素的作用而发展为癌。
In order to investigate the relationship between hypopharyngeal cancer of larynx cancer and smoking, drinking and chromosomal susceptibility, 154 cases of laryngeal and hypopharyngeal cancer and 107 normal controls were studied. The results showed that smoking and drinkers were significantly higher risk of cancer than non-smoking drinkers, cancer risk increases with the amount of tobacco and alcohol increased. Chromosome sensitivity to mutagenic experiments show that the number of chromatid per cell (b / c value) is an important indicator of the body’s sensitivity to mutagenic or carcinogens. At a b / c value of 0.40 as a sensitive value, about 80% of cases were higher than this value and 80% of the control group was below this value. According to the findings, we believe that the occurrence of hypopharyngeal carcinoma of the larynx is mainly determined by the constitutional factors. The patients with laryngeal and hypopharyngeal carcinoma are the people with higher sensitivity to carcinogens combined with environmental factors such as long-term smoking and drinking, Develop into cancer.