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目的 探讨C-erbB-2在乳腺癌中的表达及与淋巴结转移的关系。方法 用免疫组织化学ABC法检测48例乳腺癌和10例乳腺良性疾病组织中C-erbB-2的表达。结果 1O例乳腺良性疾病有1例表达阳性(10.00％),而48例乳腺癌中有32例表达阳性(66.67％)。C-erbB-2的表达与淋巴结转移与否无明显相关性,而与肿瘤病理组织类型显著相关。结论 C-erbB-2过表达在乳腺癌发生发展中起一定作用,并可作为判断乳腺癌生物行为的一个有用指标。
Objective To investigate the expression of C-erbB-2 in breast cancer and its relationship with lymph node metastasis. Methods Immunohistochemical ABC method was used to detect the expression of C-erbB-2 in 48 cases of breast cancer and 10 cases of benign breast diseases. Results 1O cases of breast benign disease were positive in 1 case (10.00%), while in 48 cases of breast cancer, 32 cases were positive (66.67%). There was no significant correlation between the expression of C-erbB-2 and lymph node metastasis, but it was significantly correlated with the type of tumor pathology. Conclusion C-erbB-2 overexpression plays a role in the development of breast cancer and may be used as a useful indicator to judge the biological behavior of breast cancer.