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地衣是被广泛用于传统药物中的独特个体.本文对一类地衣,Parmotrema cooperi,进行了生物测定引导的植物化学研究和生物活性评价.对该类地衣的首次生物测定引导的化学研究分离出了化合物ethyl heamatomate(1),atraric acid(2),ethyl orsellinate(3),orsellinic acid(4),lecanoric acid(5),gyrophoric acid(6)以及licanorin(7).化合物1～7的结构主要通过一维、二维核磁共振谱和质谱等谱学方法判定.对这些化合物还进行了抗醣化活性以及尿素酶、α-胰凝乳蛋白酶、β-葡萄糖醛酸苷酶抑制活性的评价.这些苯酚化合物没有显示特别好的活性,但其中大部分对蛋白质醣化和尿素酶活性具有较好的抑制作用.
Lichen is a unique individual that is widely used in traditional medicine.In this paper, a bioassay-directed phytochemistry and bioactivity evaluation was conducted on a group of lichens, Parmotrema cooperi, and the first bioassay guided chemical study of such lichens was isolated The compounds ethyl heamatomate (1), atraric acid (2), ethyl orsellinate (3), orsellinic acid (4), lecanoric acid (5), gyrophoric acid (6) and licanorin (7) The compounds were also evaluated for anti-glycation activity and urease, α-chymotrypsin, and β-glucuronidase inhibitory activity by one-dimensional, two-dimensional nuclear magnetic resonance spectroscopy and mass spectrometry, etc. These Phenol compounds did not show particularly good activity, but most of them had a good inhibitory effect on protein saccharification and urease activity.