近年来在对全身真菌感染 (肺、肾、皮肤粘膜等 )的发病机制研究中 ,识别出多种毒力因子如粘附、磷脂酶、蛋白酶、黑色素等。而对角膜真菌感染的相应研究极少 ,仅见于粘附和蛋白酶两方面。本文就全身及角膜真菌感染毒力的研究进展作一综述 ,以期为研究角膜真菌感染发病机制提供借鉴和方向。 In recent years, systemic pathogenic fungal infections (lung, kidney, skin and mucous membranes, etc.) in the pathogenesis of identifying a variety of virulence factors such as adhesion, phospholipase, protease, melanin and so on. The corneal fungal infection, the corresponding research is very rare, only seen in both adhesion and protease. This article reviews the research progress of systemic and corneal fungal virulence in order to provide reference and direction for studying the pathogenesis of corneal fungal infection.