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目的探讨实弹演习火炮打击后,不同位置掩体保护下兔脑组织病理及NMDA-R1表达的变化。方法闽南山地团进攻演习,30只实验兔随机分为空白对照组,反角隐蔽组和迎面隐蔽组。火炮打击应激损伤后6 h,各组存活兔取脑组织,观察其病理损伤形态学及NMDA-R1表达的变化。结果与空白对照组比较,反角隐蔽组和迎面隐蔽组NMDA-R1表达强阳性,脑组织结构层次被破坏,神经细胞变性坏死,间质出血;迎面隐蔽组NMDA-R1免疫反应强度亦高于反角隐蔽组。结论火炮打击后兔脑组织应激损伤反应强烈,反角掩体保护能够减轻脑组织损伤,NMDA-R1参与脑组织损伤病理过程。
Objective To investigate the changes of brain tissue pathology and the expression of NMDA-R1 in rabbit shelters with different positions after the firearms were hit by live ammunition. Methods An experiment was conducted in Minnan Mountain Regiment. Thirty rabbits were randomly divided into blank control group, contralateral dip concealment group and oncoming implicit group. At 6 h after the cannon was challenged with the stress injury, the surviving rabbits in each group were sacrificed and their histopathological changes and changes in the expression of NMDA-R1 were observed. Results Compared with the blank control group, the expression of NMDA-R1 was significantly positive in the contralateral-hiding group and on-head hiding group, the structure of brain tissue was damaged, the degeneration and necrosis of nerve cells and interstitial hemorrhage were observed. The intensity of NMDA- Anti-angle hidden group. CONCLUSIONS: The stress injury of rabbit brain tissue after the artillery attack is intense. The protection of the contralateral horn shelter can reduce the damage of brain tissue. NMDA-R1 is involved in the pathological process of brain injury.