目的　研究山莨菪碱对沙土鼠脑缺血后海马延迟性神经元死亡的影响并探讨其与纹状体多巴胺和 Ａ Ｔ Ｐ 含量变化的关系。方法　制备沙土鼠前脑缺血再灌注模型，脑缺血１０ ｍｉｎ 。３２ 只沙土鼠随机分为假手术组、脑缺血组、脑缺血再灌注组和山莨菪碱组。应用病理检查判断脑缺血后延迟性神经元死亡情况，高效液相测定纹状体 Ａ Ｔ Ｐ 和多巴胺的含量。结果　脑缺血组沙土鼠纹状体 Ａ Ｔ Ｐ 和多巴胺含量明显低于假手术组。在再灌注６０ ｍｉｎ 时，山莨菪碱组沙土鼠纹状体多巴胺和 Ａ Ｔ Ｐ 含量明显高于脑缺血再灌注组［ 多巴胺：（５９ ±１０） ｖｓ （３５ ±１４） ｍｇ·ｋｇ － １ ， Ｐ＜ ００１ ； Ａ Ｔ Ｐ：（０８２ ±０１２） ｖｓ （０６２ ±０１０） ｍ ｍｏｌ·ｋｇ－ １ ， Ｐ＜ ００５］ 。山莨菪碱组沙土鼠脑缺血后海马 Ｃ Ａ１ 区延迟性神经元死亡数目明显少于脑缺血再灌注组。结论　山莨菪碱可明显减少沙土鼠脑缺血后延迟性神经元死亡数目，机制可能与其减少脑缺血再灌注期间纹状体多巴胺释放和促进 Ａ Ｔ Ｐ 含量恢复的作用有关 Objective To study the effect of anisodamine on the delayed neuronal death in hippocampus after gerbil cerebral ischemia and to explore its relationship with the change of striatum dopamine and A T P content. Methods The model of gerbil forebrain ischemia reperfusion was prepared. The cerebral ischemia 10 min. 32 gerbils were randomly divided into sham operation group, cerebral ischemia group, cerebral ischemia reperfusion group and anisodamine group. Pathological examination was used to evaluate the delayed neuronal death after cerebral ischemia. Contents of striatal ATP and dopamine were determined by HPLC. Results The contents of A T P and dopamine in striatum of cerebral ischemic group were significantly lower than those in sham operation group. At 60 min after reperfusion, the content of dopamine and A T P in striatum of anisodamine group was significantly higher than that in cerebral ischemia-reperfusion group [(59 ± 10) vs (35 ± 1)  4) mg · kg - 1, P <001; A T P: (082 ± 012) vs (062 ± 010) m mol · kg -1, P <005 ]. In the anisodamine group, the number of delayed neuronal death in hippocampal CA1 area was significantly less than that in cerebral ischemia / reperfusion group after gerbil ischemia. Conclusion Anisodamine can significantly reduce the number of delayed neuronal death in gerbils after cerebral ischemia, which may be related to its role in reducing the release of dopamine and promoting the recovery of A T P during cerebral ischemia-reperfusion