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目的:探讨鹿茸对盐酸-乙醇诱导的小鼠胃黏膜损伤的保护作用。方法:将小鼠随机分成对照组、雷尼替丁组、鹿茸糖胺聚糖组、鹿茸水提取物组(低、中、高剂量)和鹿茸粉组(低、中、高剂量)。采用盐酸-乙醇诱导小鼠胃黏膜损伤,检测各组胃黏膜出血情况和损伤指数。结果:对照组小鼠胃黏膜损伤严重。与对照组相比,鹿茸糖胺聚糖组和鹿茸水提取物高剂量组对盐酸-乙醇诱导的胃黏膜损伤具有不同程度的保护作用。结论:鹿茸中糖胺聚糖和蛋白质类成分可以保护胃黏膜免受胃液中H+以及乙醇损伤,对胃黏膜起到保护作用,提示其可用作功能性食品添加物用于胃酸过多及饮酒过度人群。
Objective: To investigate the protective effect of antler on gastric mucosal injury induced by hydrochloric acid-ethanol in mice. Methods: The mice were randomly divided into control group, ranitidine group, pilose antler glycosaminoglycan group, antler water extract group (low, medium and high dose) and antler powder group (low, medium and high dose). Gastric mucosal injury was induced by hydrochloric acid-ethanol in mice, and gastric mucosal hemorrhage and injury index of each group were detected. Results: The mice in the control group had severe gastric mucosal injury. Compared with the control group, the antler glycosaminoglycan group and antler water extract high-dose group had different degrees of protective effect on gastric mucosal injury induced by hydrochloric acid-ethanol. Conclusion: The glycosaminoglycan and protein components of pilose antlers can protect the gastric mucosa from H + and alcohol in gastric juice and protect gastric mucosa, suggesting that it can be used as a functional food additive for hyperacidity and alcohol consumption Excessive crowd.