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目前,很多医院制剂室应用折光法测定葡萄糖注射液含量,由于在测定中忽略了某些问题,致使测定结果产生很大误差,甚至将不合格产品投入临床使用。为了准确测定药液的含量,保证药品质量,提出以下几点意见。一、将所测结果换算成含水葡萄糖浓度应用折光法测定葡萄糖注射液含量,常直接读取阿贝折光仪观察镜中所示数值,作为样品百分含量。实际上此值为20℃时溶液所含无水葡萄糖浓度,如按此值算出结果必然偏低。因为中国药典1977年版收载葡萄糖注射液的含量按含水葡萄糖计算,所以应将所测结果按下
At present, many hospital preparation rooms use the refraction method to determine the content of glucose injection. Due to the omission of certain problems in the measurement, the measurement results have a great error, and even put the substandard products into clinical use. In order to accurately determine the content of liquid medicine to ensure the quality of medicines, put forward the following comments. First, the measured results will be converted to aqueous glucose concentration using the refractive index of glucose injection, often directly read Abbe refractometer observed value shown in the mirror, as the sample percentage. In fact, this value is 20 ℃ when the solution contains anhydrous glucose concentration, calculated according to this value is bound to be low. Because the Chinese Pharmacopoeia 1977 edition containing glucose injection content calculated according to hydrous glucose, it should be measured by the press