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目的:了解女性冠心病患者的危险因素及与冠脉病变严重程度的关系。方法:随机选取本院2012年至2014年心血管科住院治疗的疑似冠心病女性患者150例,经冠脉造影确诊冠心病患者105例,非冠心病患者45例。对患者的临床资料和冠脉病变严重程度进行单因素和多因素分析。结果:冠心病患者高血压与糖尿病百分比、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)及纤维蛋白原水平均高于非冠心病患者,而高密度脂蛋白(HDL-C)和血红蛋白水平均低于非冠心病患者(P<0.05);年龄、高血压与糖尿病百分比、血脂上升百分比(高TC、高TG、低HDL-C、高LDL-C)、高尿酸百分比和纤维蛋白原水平均随冠状动脉病变支数及Gensini积分的增加而增加(P<0.05);多因素分析发现女性冠心病的影响因素分别为高LDL-C、糖尿病、低HDL-C、TG和高血压,其中高LDL-C的影响最为显著(P<0.05)。结论:高血压、糖尿病史、血脂水平为女性冠心病的影响因素,其中高LDL-C的影响最显著,各影响因素均与冠脉病变程度紧密相关。
Objective: To understand the risk factors of coronary heart disease in women and its relationship with the severity of coronary artery disease. Methods: A total of 150 women with suspected coronary heart disease admitted to our hospital from 2012 to 2014 in our hospital were selected randomly. 105 patients with coronary heart disease confirmed by coronary angiography and 45 patients with non-coronary heart disease were enrolled. The clinical data of patients and the severity of coronary lesions were univariate and multivariate analysis. Results: The levels of hypertension and diabetes, triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL-C) and fibrinogen in patients with coronary heart disease were higher than those without coronary heart disease, while high density lipoprotein (HDL-C) and hemoglobin levels were lower than those of non-CHD patients (P <0.05); age, the percentage of hypertension and diabetes, the percentages of lipids up (high TC, high TG, low HDL-C and high LDL-C) The percentages of high uric acid and fibrinogen both increased with the number of coronary lesions and Gensini integral (P <0.05). Multivariate analysis showed that the influencing factors of coronary heart disease were high LDL-C, diabetes, low HDL-C , TG and hypertension, among which the effect of high LDL-C was the most significant (P <0.05). Conclusion: Hypertension, history of diabetes mellitus and blood lipid levels are the influencing factors of coronary heart disease in women. Among them, the effect of high LDL-C is the most significant, and all the influencing factors are closely related to the degree of coronary artery disease.