早在１８９５年，德国的Ｒｅｈｎｕ就报道染料工人比普通人群易发生膀胱癌，随后美国、意大利、法国、瑞士、日本等国学者也在染料生产工人中发现了膀胱癌患者，并通过动物实验资料证实了β－萘胺和联苯胺有很强的致癌性。１９７３年８月致癌物质标准咨询委员会向美国劳工部提? As early as 1895, Germany’s Rehnu reported that dye workers were more prone to bladder cancer than the general population. Subsequently, scholars from the United States, Italy, France, Switzerland, Japan and other countries also found bladder cancer patients in dye production workers and passed animal experimental data Confirmed β-naphthylamine and benzidine have strong carcinogenicity. August 1973 Carcinogen Standards Advisory Committee to the United States Department of Labor?