为了观察乙肝疫苗第三针减量接种后的效果 ,对 12 6名接种乙肝疫苗于第三针减量接种 (接种剂量分别为 2μg,5 μg,10 μg,2 0 μg或未接种 )的儿童进行了长达 9年的追踪观察。结果显示 9年中各组抗体水平 ( GMT)均无显著性差异( P>0 .0 5 ) ,第 9年 ( T1 0 8)时各组 GMT分别为 7.0 ,6 .4,9.9,6 .1,9.7,5 .4和 7.4,HBV人年感染率各组亦无显著性差异( P>0 .0 5 ) ,疫苗保护率各组均大于 75 %。表明疫苗初种第三针减量不影响疫苗近、远期效果 In order to observe the effect of hepatitis B vaccine after the third dose reduction inoculation, 12 6 children vaccinated with hepatitis B vaccine in the third dose reduction vaccination (2 μg, 5 μg, 10 μg, 20 μg, or unvaccinated) After 9 years of follow-up observation. The results showed that there was no significant difference in antibody levels (GMT) between the two groups at 9 years (P> 0.05), and at the 9th year (T1 0 8) GMT was 7.0, 6.4, 9.9 and 6 respectively. 1,9.7,5. 4 and 7.4, HBV infection rate in each group also showed no significant difference (P> 0.05), the vaccine protection rate in each group were more than 75%. The first three doses of vaccines showed that the vaccine did not affect the near and long-term effects of the vaccine