临床诊断的肝细胞型急性药物性肝损伤患者血清ALT/ALP比值变化特点与组织病理学特征分析

来源 :实用肝脏病杂志 | 被引量 : 0次 | 上传用户：lrdw149

【摘要】

：

目的探讨药物性肝损伤(DILI)患者临床分型的变化及其组织病理学特征。方法2018年8月~2019年8月入院临床诊断为肝细胞型DILI患者43例,在入院治疗2周后行肝穿活检,在病理学检查

【作者】

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黄春洋陈杰张小丹黄云丽韩莹李文娟边新渠廖慧钰

【机构】

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首都医科大学附属北京佑安医院肝病中心二科

【出处】

：

实用肝脏病杂志

【发表日期】

：

2021年3期

【关键词】

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药物性肝损伤临床分型变化 Drug-induced liver injury Clinical type Dynamic

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论文部分内容阅读

目的探讨药物性肝损伤(DILI)患者临床分型的变化及其组织病理学特征。方法2018年8月~2019年8月入院临床诊断为肝细胞型DILI患者43例,在入院治疗2周后行肝穿活检,在病理学检查当日再次根据临床指标确定临床分型,观察组织病理学特征。结果43例临床诊断的肝细胞型DILI患者在肝穿时血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(TBIL)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(GGT)和总胆汁酸(TBA)水平已显著降低,其R值较入院时也显著下降(19.6±1

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临床诊断的肝细胞型急性药物性肝损伤患者血清ALT/ALP比值变化特点与组织病理学特征分析

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