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南京医学院硕士研究生查文章近日完成的“原发性肝癌与丙型肝炎病毒关系”的研究,成功地从基因水平证实了丙型肝炎是我国肝癌发病第二相关因素。查文章在其导师杜竞辉、王学浩教授指导下,对101例原发性肝癌外周血、48例肝癌组织及癌旁组织,进行丙肝病毒基因和抗体的对照研究,发现肝癌病人中丙肝抗体阳性率为9.9％,丙肝病毒基因检测率为13.2％,丙肝感染率为14.5％,均比正常人高出10倍以上。该研究证实了丙肝病毒基因的复制是在丙肝感染的肝癌及癌旁组织,有可能构成致癌作用的启动因子。
Nanjing Medical College graduate student investigation article recently completed the “primary liver cancer and hepatitis C virus,” the study successfully from the gene level confirmed that hepatitis C is the second factor in the incidence of liver cancer in our country. Under the guidance of their tutors Du Jinghui and Wang Xuehao, 101 articles of primary hepatocellular carcinoma, 48 cases of hepatocellular carcinoma and adjacent tissues were investigated for the control of hepatitis C virus gene and antibody. The positive rate of hepatitis C virus in patients with hepatocellular carcinoma was 9.9%, the detection rate of hepatitis C virus gene was 13.2% and the infection rate of hepatitis C was 14.5%, which were more than 10 times higher than that of normal people. The study confirmed that hepatitis C virus gene replication in hepatitis C-infected liver and paracancerous tissues, may constitute a promoter of oncogenic effects.