患者男性、49岁、工人。因咽痛、发热、腹泻、乏力6天。于1982年5月25日入院。病案号21750。体检:体温38℃、脉搏104次、血压94/56mmHg。皮肤巩膜无黄染、咽部充血、扁桃体不肿大,心肺无异常,肝肋下1.5cm,脾未触及。血象:红细胞223万,血红蛋白7g/dl,白细胞4.200,中性42%,嗜酸1%,淋巴56%,单核1%。血小板4.3万。网织红细胞缺如。GPT230u(正常100u 以下)。胸透两肺纹理增强,心电图正常。入院前后因高热先后用安痛定10支,血象呈进行性下降。6月4日白细胞450,中性5%、淋巴94%。红细胞255万,血红蛋白8g/dl,血小板3.4万,骨髓增生低下,粒红二系极少,淋巴细胞、浆细胞、网状细胞比例增高。巨核细胞未见。一度考虑为再生障碍性贫血(再障)。重阅原骨髓片,可见数个体积极大的原始细胞,胞体圆形、直径28～35微米。浆少、深蓝不透明、有环核浅 Male patient, 49 years old, worker. Due to sore throat, fever, diarrhea, fatigue 6 days. May 25, 1982 admitted to hospital. Case No. 21750. Physical examination: body temperature 38 ℃, pulse 104 times, blood pressure 94/56 mmHg. Skin sclera no yellow dye, pharynx congestion, tonsil does not enlarge, no abnormal heart and lung, hepatic ribs 1.5cm, spleen not touched. Blood: 2230000 erythrocytes, hemoglobin 7g / dl, leukocytes 4.200, 42% neutral, 1% eosinophilic, lymphatic 56%, mononuclear 1%. 43,000 platelets. Reticulocyte absent. GPT230u (below normal 100u). Thoracotomy two lungs enhanced texture, normal ECG. Before and after admission due to high fever, there are 10 with Anyong, blood was decreased. June 4 white blood cells 450, 5% neutral, lymph 94%. 2.55 million red blood cells, hemoglobin 8g / dl, platelets 34,000, low myeloid hyperplasia, very few grainy two lines, lymphocytes, plasma cells, increased proportion of reticulocytes. Megakaryocytes have not seen. Once considered as aplastic anemia (aplastic anemia). Re-read the original bone marrow, we can see a number of very large primitive cells, cell body round, 28 to 35 microns in diameter. Less pulp, dark blue opaque, ring nuclear shallow