论文部分内容阅读
目的:研究裂褶菌发酵物对模拟缺氧大鼠糖代谢关键酶活性的影响。方法:采用小鼠密闭缺氧存活实验筛选抗缺氧功能发酵物,考察裂褶菌发酵物对大鼠神经元细胞缺氧缺糖损伤保护作用,并研究其对缺氧大鼠骨骼肌(腓肠肌)、左心室和右心室心肌的琥珀酸脱氢酶、乳酸脱氢酶活性的影响。结果:裂褶菌发酵物具有显著的抗缺氧功能,在一定浓度范围内可显著提高缺氧缺糖神经元细胞的存活率。裂褶菌发酵物可显著提高左心室琥珀酸脱氢酶活性,同时对右心室的琥珀酸脱氢酶活性具有一定的影响。结论:裂褶菌发酵物的抗缺氧机制与提高心肌琥珀酸脱氢酶活性有关。
Objective: To study the effect of schizophyllum commune fermentation on the key enzymes of glucose metabolism in simulated hypoxia rats. Methods: Anti-hypoxia functional ferment was screened in airtight hypoxia-survival test in mice to observe the protective effect of schizophyllum commune on neuronal cell injury induced by hypoxia and hypoglycemia, and to investigate its protective effect on skeletal muscle (gastrocnemius ), Left and right ventricular myocardial succinate dehydrogenase, lactate dehydrogenase activity. Results: Schizophyllacetica fermentation had significant anti-hypoxia function, and could significantly increase the survival rate of hypoxic-glucose deprivation neurons in a certain concentration range. Schizophyllan fermentation can significantly improve the activity of succinate dehydrogenase in the left ventricle, while having a certain impact on the activity of succinate dehydrogenase in the right ventricle. Conclusion: The mechanism of anti-hypoxia of schizophyllum commune is related to the improvement of myocardial succinate dehydrogenase activity.